Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
National Institutes of Health · Oral Diseases and Disorders Research (93.121)
Publicada 31 oct 2024 · Quedan aproximadamente 8 meses
En pocas palabras
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The National Institutes of Health funds mechanistic research on precision probiotic therapies to understand why some people respond better to probiotics than others, using animal models or human studies. Applicants must be U.S.-based organizations including nonprofits, universities, government agencies, and small businesses, with applications due by 2 June 2027.
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Resumen
Texto original del donante (inglés)
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses.
This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as…
Extracto de la página del donante. El texto completo, los anexos y los formularios están en la convocatoria original.
Quién puede presentar una solicitud
- ONG / sociedad civil
- Institución académica o de investigación
- Organismo gubernamental
- Empresa privada
- Empresa social o cooperativa
- Organización comunitaria
Elegibilidad y condiciones
Mostrar el texto de elegibilidad de la fuente · Texto original del donante (inglés)
Applicant types: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; State governments; Private institutions of higher education; Special district governments; Small businesses; City or township governments; Native American tribal governments (Federally recognized); For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Native American tribal organizations (other than Federally recognized tribal governments)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.