Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
National Institutes of Health · Oral Diseases and Disorders Research (93.121)
Publié 31 oct. 2024 · Environ 8 mois restants
En clair
Résumé pas encore disponible en français ; affiché en anglais.
The National Institutes of Health funds mechanistic research on precision probiotic therapies to understand why some people respond better to probiotics than others, using animal models or human studies. Applicants must be U.S.-based organizations including nonprofits, universities, government agencies, and small businesses, with applications due by 2 June 2027.
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Résumé
Texte original du bailleur (anglais)
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses.
This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as…
Extrait de la page du bailleur. Le texte intégral, les annexes et les formulaires se trouvent dans l'appel original.
Qui peut candidater
- ONG / société civile
- Établissement universitaire ou de recherche
- Organisme public
- Entreprise privée
- Entreprise sociale ou coopérative
- Organisation communautaire
Éligibilité et conditions
Afficher le texte d'éligibilité de la source · Texte original du bailleur (anglais)
Applicant types: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; State governments; Private institutions of higher education; Special district governments; Small businesses; City or township governments; Native American tribal governments (Federally recognized); For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Native American tribal organizations (other than Federally recognized tribal governments)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.