Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)
National Institutes of Health · Mental Health Research Grants (93.242)
Publié 22 nov. 2024 · 42 jours restants
En clair
Résumé pas encore disponible en français ; affiché en anglais.
The US National Institutes of Health funds Phase 1 through 2a clinical trials of novel drugs for Alzheimer's disease and related dementias, including non-amyloid and non-tau mechanisms targeting cognitive or neuropsychiatric symptoms. Applicants may be universities, research institutions, nonprofits, companies, government agencies, and foreign organizations, with applications due by 19 November 2026.
Un résumé généré du texte du bailleur ; la formulation originale figure ci-dessous.
Résumé
Texte original du bailleur (anglais)
The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsychiatric symptoms in individuals across the spectrum from pre-symptomatic to more severe stages of disease. This NOFO uses the UG3/UH3 phased award mechanism and proposals must include prespecified, go/no-go safety and tolerability milestones that gate the advance from phase 1 to latter stages of clinical development.
Extrait de la page du bailleur. Le texte intégral, les annexes et les formulaires se trouvent dans l'appel original.
Qui peut candidater
- Entreprise privée
- Établissement universitaire ou de recherche
- Organisme public
- ONG / société civile
- Organisation communautaire
Éligibilité et conditions
Afficher le texte d'éligibilité de la source · Texte original du bailleur (anglais)
Applicant types: Native American tribal organizations (other than Federally recognized tribal governments); For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Others (see text field entitled "Additional Information on Eligibility" for clarification); City or township governments; Independent school districts; Native American tribal governments (Federally recognized); State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Private institutions of higher education; County governments; Small businesses
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.