Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)
National Institutes of Health · Mental Health Research Grants (93.242)
Posted 22 Nov 2024 · 49 days left
In plain terms
The US National Institutes of Health funds Phase 1 through 2a clinical trials of novel drugs for Alzheimer's disease and related dementias, including non-amyloid and non-tau mechanisms targeting cognitive or neuropsychiatric symptoms. Applicants may be universities, research institutions, nonprofits, companies, government agencies, and foreign organizations, with applications due by 19 November 2026.
A generated summary of the donor's text; the original wording is below.
Summary
The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsychiatric symptoms in individuals across the spectrum from pre-symptomatic to more severe stages of disease. This NOFO uses the UG3/UH3 phased award mechanism and proposals must include prespecified, go/no-go safety and tolerability milestones that gate the advance from phase 1 to latter stages of clinical development.
Excerpt from the donor's page. The full text, annexes and forms are on the original call.
Who can apply
- private_company
- academia_research
- government
- ngo_cso
- community_based_org
Eligibility and conditions
Show the eligibility text from the source
Applicant types: For profit organizations other than small businesses; Public and State controlled institutions of higher education; State governments; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Special district governments; Public housing authorities/Indian housing authorities; Small businesses; Native American tribal governments (Federally recognized); County governments; Independent school districts; Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.