Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
National Institutes of Health · Mental Health Research Grants (93.242)
Posted 4 May 2026 · About 5 months left
In plain terms
The US National Institutes of Health funds research to discover and develop novel chemical probes and biological targets relevant to mental health, drug abuse, aging, and vision research. Applicants including non-U.S. organisations, nonprofits, businesses, governments, and academic institutions may apply by 5 March 2027 with validated starting compounds and testing bioassays in hand.
A generated summary of the donor's text; the original wording is below.
Summary
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.
Excerpt from the donor's page. The full text, annexes and forms are on the original call.
Eligible regions
- global
Who can apply
- government
- private_company
- ngo_cso
- academia_research
- community_based_org
Eligibility and conditions
Show the eligibility text from the source
Applicant types: County governments; Small businesses; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; Private institutions of higher education; City or township governments; Public housing authorities/Indian housing authorities; Independent school districts; Special district governments; Others (see text field entitled "Additional Information on Eligibility" for clarification)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.