NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)
National Institutes of Health · Research and Training in Complementary and Integrative Health (93.213)
Posted 2 Dec 2024 · 43 days left
In plain terms
The National Institutes of Health funds early-phase clinical trials of natural products such as botanicals and dietary supplements with strong scientific promise, offering up to three years of support with potential extension. Grants up to 350,000 US dollars are available to US-based research institutions, non-profits, and government agencies, with applications due by 13 November 2026.
A generated summary of the donor's text; the original wording is below.
Summary
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, probiotics, and products marketed as dietary supplements), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product.
This NOFO will provide up to three years (R61 phase) of support for milestone-driven testing of pharmacokinetics, bioavailability, and assessment of the natural products effect (i.e., measure of mechanism of action) when used by humans on a specified target measure. If milestones in the R61 phase are achieved, up to 3 years of additional support (R33 phase) may be awarded to replicate the impact of the natural…
Excerpt from the donor's page. The full text, annexes and forms are on the original call.
Who can apply
- academia_research
- private_company
- ngo_cso
- government
- community_based_org
Eligibility and conditions
Show the eligibility text from the source
Applicant types: Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; Others (see text field entitled "Additional Information on Eligibility" for clarification); Special district governments; For profit organizations other than small businesses; State governments; County governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; Public and State controlled institutions of higher education; Private institutions of higher education; Small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.