Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)
National Institutes of Health · Aging Research (93.866)
Publié 3 nov. 2026 · Environ 24 mois restants
En clair
Cet avis de financement (NOFO) soutient la traduction des thérapies par édition du génome et autres thérapies biologiques pour les démences liées à la maladie d’Alzheimer (ADRD). Le programme couvre l’ensemble de la filière translationnelle, depuis l’optimisation des candidats thérapeutiques et le développement du produit médicamenteux jusqu’aux études permettant la demande d’essai clinique (IND) et à l’évaluation clinique précoce.
Résumé tiré du texte du bailleur, traduit automatiquement ; la formulation originale figure ci-dessous.
Résumé
Texte original du bailleur (anglais)
This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation. Supported activities may include optimization of editing constructs and delivery systems; assessment of bioactivity, target engagement, durability, pharmacokinetics, and bioavailability; demonstration of in vivo efficacy; execution of safety pharmacology and toxicology studies; and development of scalable manufacturing processes, formulation strategies, and quality attributes aligned with regulatory expectations.
ADRD include Frontotemporal Dementia (FTD); Lewy Body Dementias (LBD), including Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD); Vascular Contributions to Cognitive Impairment and Dementia (VCID); and Multiple Etiology Dementias (MED).
Extrait de la page du bailleur. Le texte intégral, les annexes et les formulaires se trouvent dans l'appel original.
Qui peut candidater
- Établissement universitaire ou de recherche
- Organisme public
- ONG / société civile
- Entreprise privée
- Organisation communautaire
Éligibilité et conditions
Afficher le texte d'éligibilité de la source · Texte original du bailleur (anglais)
Applicant types: Private institutions of higher education; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); For profit organizations other than small businesses; Native American tribal governments (Federally recognized); State governments; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); County governments; Small businesses; Independent school districts; Special district governments
Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).