Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)
National Institutes of Health · Aging Research (93.866)
Опубликован 3 нояб. 2026 г. · Осталось примерно 24 месяца
Простыми словами
Это Уведомление о возможности финансирования (NOFO) поддерживает трансляцию методов редактирования генома и других биологических терапий для деменций, связанных с болезнью Альцгеймера (ADRD). Программа охватывает весь трансляционный цикл — от оптимизации лидов терапевтических препаратов и разработки лекарственного продукта до доклинических исследований, обеспечивающих подачу IND, и ранней клинической оценки.
Краткое изложение по тексту донора, переведено автоматически; оригинальная формулировка приведена ниже.
Краткое описание
Исходный текст донора (английский)
This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation. Supported activities may include optimization of editing constructs and delivery systems; assessment of bioactivity, target engagement, durability, pharmacokinetics, and bioavailability; demonstration of in vivo efficacy; execution of safety pharmacology and toxicology studies; and development of scalable manufacturing processes, formulation strategies, and quality attributes aligned with regulatory expectations.
ADRD include Frontotemporal Dementia (FTD); Lewy Body Dementias (LBD), including Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD); Vascular Contributions to Cognitive Impairment and Dementia (VCID); and Multiple Etiology Dementias (MED).
Фрагмент со страницы донора. Полный текст, приложения и формы — в исходном объявлении о конкурсе.
Кто может подать заявку
- Академическое или исследовательское учреждение
- Государственный орган
- НКО / гражданское общество
- Частная компания
- Организация местного сообщества
Требования и условия
Показать требования из источника · Исходный текст донора (английский)
Applicant types: Private institutions of higher education; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); For profit organizations other than small businesses; Native American tribal governments (Federally recognized); State governments; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); County governments; Small businesses; Independent school districts; Special district governments
Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).