Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)
National Institutes of Health · Aging Research (93.866)
Posted 3 Nov 2026 · About 24 months left
In plain terms
This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation.
Summary from the donor's own text; the full wording is below.
Summary
This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation. Supported activities may include optimization of editing constructs and delivery systems; assessment of bioactivity, target engagement, durability, pharmacokinetics, and bioavailability; demonstration of in vivo efficacy; execution of safety pharmacology and toxicology studies; and development of scalable manufacturing processes, formulation strategies, and quality attributes aligned with regulatory expectations.
ADRD include Frontotemporal Dementia (FTD); Lewy Body Dementias (LBD), including Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD); Vascular Contributions to Cognitive Impairment and Dementia (VCID); and Multiple Etiology Dementias (MED).
Excerpt from the donor's page. The full text, annexes and forms are on the original call.
Who can apply
- Academic or research institution
- Government body
- NGO / civil society
- Private company
- Community-based organisation
Eligibility and conditions
Show the eligibility text from the source
Applicant types: Private institutions of higher education; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); For profit organizations other than small businesses; Native American tribal governments (Federally recognized); State governments; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); County governments; Small businesses; Independent school districts; Special district governments
Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).